Department of Oriental Pharmacy, College of Pharmacy, Wonkwang University, 344-2 Shinyong-dong, Iksan, Jeonbuk, 570-749, Republic of Korea. Tel/
Evid Based Complement Alternat Med. 2009 Sep;6 Suppl 1(Suppl 1):73-80. doi: 10.1093/ecam/nep118.
Multidrug resistance 1 (MDR1) is a gene that expresses P-glycoprotein (P-gp), a drug transporter protein. Genetic polymorphisms of MDR1 can be associated with Sasang constitutions because Sasang constitutional medicine (SCM) prescribes different drugs according to different constitutions. A Questionnaire for Sasang Constitution Classification II (QSCC II) was used to diagnose Sasang constitutions. Two hundred and seven healthy people whose Sasang constitutions had been identified were tested. Genotype analyses, restriction fragment length polymorphism (RFLP) and pyrosequencing were used in MDR1 C1236T, and in MDR1 G2677T/A and C3435T, respectively. Significant differences in MDR1 C1236T genotypes were found between So-yangin and So-eumin. MDR1 G2677T/A genotype also showed significant differences in allele distribution between So-yangin and Tae-eumin. So-yangin and So-eumin showed significant differences in the distribution of both 1236C-2677G-3435C and 1236T-2677G-3435T, haplotypes of MDR1. The genetic polymorphism of the MDR1 gene was thus shown to be an indicator that could distinguish So-yangin from other constitutions.
多药耐药基因 1（MDR1）是一种表达 P-糖蛋白（P-gp）的基因，P-糖蛋白是一种药物转运蛋白。MDR1 的遗传多态性可能与沙参体质有关，因为沙参体质医学（SCM）根据不同的体质开不同的药物。使用沙参体质分类问卷 II（QSCC II）来诊断沙参体质。对 207 名已确定沙参体质的健康人进行了测试。对 MDR1 C1236T 进行基因型分析、限制性片段长度多态性（RFLP）和焦磷酸测序，对 MDR1 G2677T/A 和 C3435T 分别进行 RFLP 和焦磷酸测序。在 So-yangin 和 So-eumin 之间发现 MDR1 C1236T 基因型存在显著差异。MDR1 G2677T/A 基因型在 So-yangin 和 Tae-eumin 之间的等位基因分布也存在显著差异。So-yangin 和 So-eumin 在 MDR1 1236C-2677G-3435C 和 1236T-2677G-3435T 两种单倍型的分布上存在显著差异。因此，MDR1 基因的遗传多态性被证明是区分 So-yangin 与其他体质的指标。
