Lin F K, Hung K L, Wang N K
Department of Pediatrics, Cathay General Hospital, Taipei, Taiwan, R.O.C.
J Formos Med Assoc. 1990 Mar;89(3):190-3.
A pulsed-Doppler real-time technique was used to assess the anterior cerebral artery (ACA) flow velocity in 30 asphyxiated infants during the first 5 days after birth. Thirty healthy term infants were also studied as controls. Peak systolic flow velocity (PSFV), end diastolic flow velocity (EDFV), mean flow velocity (MFV), and pulsatility index (PI) were measured. Mean PI values of the ACA of the asphyxiated and control groups were 0.63 +/- 0.05 vs 0.71 +/- 0.04 (p less than 0.001) on the first day; 0.64 +/- 0.03 vs 0.70 +/- 0.05 (p less than 0.001) on the third day and 0.69 +/- 0.04 vs 0.70 +/- 0.04 (p greater than 0.05) on the fifth day of life. The asphyxiated group also had significantly higher EDFV and MFV than those of control group until the 5th day of life. The low PI values of asphyxiated infants were mainly due to an increase in EDFV. These results suggest that the cerebrovascular resistance of asphyxiated infants, as reflected by the PI, is low during the first 3 days of life, indicating an increase in cerebral blood flow. With this technique, we can repeatedly and safely evaluate the cerebral hemodynamic changes in asphyxiated newborn infants.
采用脉冲多普勒实时技术，对30例窒息婴儿出生后前5天的大脑前动脉（ACA）血流速度进行评估。还对30例健康足月儿进行了研究作为对照。测量了收缩期峰值血流速度（PSFV）、舒张末期血流速度（EDFV）、平均血流速度（MFV）和搏动指数（PI）。窒息组和对照组ACA的平均PI值在出生第一天分别为0.63±0.05和0.71±0.04（p<0.001）；出生第三天分别为0.64±0.03和0.70±0.05（p<0.001）；出生第五天分别为0.69±0.04和0.70±0.04（p>0.05）。直到出生第5天，窒息组的EDFV和MFV也显著高于对照组。窒息婴儿的低PI值主要是由于EDFV增加。这些结果表明，以PI反映的窒息婴儿脑血管阻力在出生后前3天较低，表明脑血流量增加。通过这项技术，我们可以反复、安全地评估窒息新生儿的脑血流动力学变化。
