Department of Pediatrics, Saitama Medical Center, Jichi Medical University, 1-847 Amanuma, Omiya, Saitama-shi, Saitama, 330-8503, Japan.
J Med Ultrason (2001). 2020 Oct;47(4):635-640. doi: 10.1007/s10396-020-01041-7. Epub 2020 Jul 28.
To quantitatively estimate the influence of ductal shunt on cerebral blood flow and establish a new index of ultrasonography for estimating cerebral circulation without the influence of ductal shunt in newborn infants.
We retrospectively examined the records of anterior cerebral artery (ACA) and left pulmonary artery (LPA) blood flow velocity curves recorded by pulsed Doppler ultrasonography within 6 h after birth in 123 newborn infants without asphyxia (normal group) and in 31 newborn infants with asphyxia (asphyxia group).
In the normal group, the resistance index (RI) of the ACA showed a positive correlation with the ratio of LPA diastolic-to-systolic flow velocities (LPAD/LPAS) (P < 0.001, r = 0.58), and the estimated RI (eRI) of the ACA was calculated using the following formula: Y = 0.47X + 0.67 (Y estimated RI; X LPAD/LPAS). In the asphyxia group, the RI of the ACA showed a weak correlation to base excess (BE) (P < 0.05, r = 0.46). The eRI of the ACA was calculated by the LPAD/PLAS in the asphyxia group, and the difference between the RI and eRI showed a better correlation to BE than RI (P < 0.001, r = 0.64).
We determined the relation between cerebral blood flow RI and ductal shunt, and (RI - eRI) may be a new useful ultrasonographic index indicating cerebral circulation without the influence of ductal shunt in newborn infants.
定量估计导管分流对脑血流的影响，并建立一种新的超声指数，用于估计新生儿脑循环，不受导管分流的影响。
我们回顾性分析了 123 例无窒息（正常组）和 31 例窒息（窒息组）新生儿出生后 6 小时内经脉冲多普勒超声记录的大脑前动脉（ACA）和左肺动脉（LPA）血流速度曲线。
在正常组中，ACA 的阻力指数（RI）与 LPA 舒张期与收缩期流速比（LPAD/LPAS）呈正相关（P<0.001，r=0.58），并使用以下公式计算 ACA 的估计 RI（eRI）：Y=0.47X+0.67（Y 估计 RI；X LPAD/LPAS）。在窒息组中，ACA 的 RI 与碱剩余（BE）呈弱相关（P<0.05，r=0.46）。通过 LPAD/PLAS 在窒息组中计算 ACA 的 eRI，与 RI 相比，ACA 的 RI 和 eRI 之间的差异与 BE 具有更好的相关性（P<0.001，r=0.64）。
我们确定了脑血流 RI 与导管分流之间的关系，（RI-eRI）可能是一种新的有用的超声指数，用于指示新生儿脑循环，不受导管分流的影响。
