Wiens Matthew, Gordon Wendy, Baulcomb Daisy, Mattman Andre, Mock Tom, Brown Robert
Department of Pharmacy, Chilliwack General Hospital, Chilliwack, British Columbia, Canada.
Can J Cardiol. 2009 Sep;25(9):e329-31. doi: 10.1016/s0828-282x(09)70147-3.
The chloride salt of cesium, a group 1A element, is gaining popularity as an alternative treatment of advanced cancers. Cesium chloride has primarily been used in cardiovascular research for arrhythmogenesis in animals because of its potassium-blocking effects. The present report describes a 45-year-old woman with metastatic breast cancer who experienced repeated episodes of torsades de pointes polymorphic ventricular tachycardia after several months of oral cesium therapy. There was a clear temporal relationship between cesium ingestion and the arrhythmia, which later resolved following discontinuation of cesium therapy. Serial cesium plasma and whole blood levels were measured over the ensuing six months and pharmacokinetic analysis was performed.
铯（一种第1A族元素）的氯化物正作为晚期癌症的替代治疗方法而越来越受欢迎。由于其钾阻断作用，氯化铯主要用于心血管研究中动物心律失常的研究。本报告描述了一名45岁的转移性乳腺癌女性患者，在口服铯治疗数月后反复出现尖端扭转型多形性室性心动过速。铯摄入与心律失常之间存在明显的时间关系，在停止铯治疗后心律失常后来得到缓解。在随后的六个月内测量了连续的铯血浆和全血水平，并进行了药代动力学分析。
