School of Pharmacy, East China University of Science & Technology, 130 Meilong road, Shanghai 200237, P.R. China.
Chem Asian J. 2009 Nov 2;4(11):1712-6. doi: 10.1002/asia.200900238.
An o-anisidine-Pd(OAc)2 catalytic system for the direct co-catalytic Saegusa oxidation of beta-aryl substituted aldehydes to alpha,beta-unsaturated aldehydes has been developed. The use of o-anisidine in place of (S)-diphenylprolinol made the process more simply and cost-effective. The process not only features the use of unmodified aldehydes rather than enol silyl ethers, but also gives moderate to good yields (44-72%).
已开发出一种邻茴香胺-Pd(OAc)2 催化体系，用于β-芳基取代的醛的直接协同 Saegusa 氧化反应，生成α,β-不饱和醛。使用邻茴香胺代替(S)-二苯基脯氨醇，使该过程更加简单和经济高效。该过程不仅使用未修饰的醛而不是烯醇硅醚，而且产率中等至良好（44-72%）。
