School of Sport Science, Exercise and Health, The University of Western Australia, Crawley, WA 6009, Australia.
Diabetes Metab. 2009 Nov;35(5):418-21. doi: 10.1016/j.diabet.2009.04.008. Epub 2009 Sep 10.
The significant deterioration of insulin sensitivity and glucose tolerance during pregnancy can have serious health implications for both the pregnant woman and her baby. Although it is well established that regular exercise benefits insulin sensitivity in the nonpregnant population, the effect on glucose tolerance in obese pregnant women is not known. The purpose of this study was to investigate the effect of a supervised 10-week, home-based, exercise programme, beginning at week 18 of gestation, on glucose tolerance and aerobic fitness in previously sedentary obese women.
Twelve sedentary obese women were randomized into an exercise (EX; n=6) or control (CON; n=6) group at 18 weeks of gestation. Those randomized to EX engaged in 10 weeks of supervised home-based exercise (three sessions a week of stationary cycling), while those in the CON group maintained their usual daily activity. Their glucose and insulin responses to an oral glucose tolerance test (OGTT), as well as their aerobic fitness, were assessed both pre- and postintervention.
Reduced glucose tolerance in the CON, but not EX, group was indicated by a tendency postintervention towards higher blood glucose levels at 1h of the OGTT (P=0.072). Furthermore, at 2h of the postintervention OGTT, blood glucose tended to remain elevated from baseline in the CON (P=0.077). There was also a trend towards increased fitness in the EX (P=0.064), but not the CON group.
Regular aerobic exercise begun during pregnancy may have favourable effects on glucose tolerance and fitness in obese women, and warrants further investigation in a larger sample population.
怀孕期间胰岛素敏感性和葡萄糖耐量的显著恶化可能对孕妇及其婴儿的健康产生严重影响。虽然众所周知，有规律的运动有益于非孕妇人群的胰岛素敏感性，但对于肥胖孕妇的葡萄糖耐量的影响尚不清楚。本研究的目的是探讨从妊娠 18 周开始，为期 10 周、家庭监督的运动方案对先前久坐不动的肥胖女性的葡萄糖耐量和有氧健身的影响。
18 周妊娠时，12 名久坐不动的肥胖女性被随机分为运动（EX；n=6）或对照组（CON；n=6）。随机分配到 EX 的人进行了 10 周的家庭监督运动（每周三次固定自行车运动），而对照组则保持日常活动。在干预前后，评估了她们对口服葡萄糖耐量试验（OGTT）的葡萄糖和胰岛素反应，以及她们的有氧健身能力。
CON 组的葡萄糖耐量降低，而 EX 组没有，这表明 OGTT 1 小时后的血糖水平在干预后有升高的趋势（P=0.072）。此外，在干预后 OGTT 的 2 小时，CON 组的血糖水平从基线开始趋于升高（P=0.077）。EX 组的体能也有增加的趋势（P=0.064），但 CON 组没有。
怀孕期间开始的有规律的有氧运动可能对肥胖女性的葡萄糖耐量和体能有有益的影响，值得在更大的样本人群中进一步研究。
