Blatt C
Department of Molecular Genetics and Virology, Weizmann Institute of Science, Rehovot, Israel.
Cancer Cells. 1990 Jun;2(6):186-9.
The homeo box genes encode proteins that function in a complex regulatory network that specifies the precise temporal and spatial expression of genes in the developing embryo. Recent work has shown that these proteins can act directly as transcription factors. I argue here that, when altered by somatic mutation, the products of homeo box genes are likely to acquire activities that contribute to the oncogenic process.
