Inamori K, Takeshita K, Chiba S, Yazaki Y, Hirai H
Third Department of Internal Medicine, Faculty of Medicine, University of Tokyo, Japan.
Biochem Biophys Res Commun. 1993 Oct 15;196(1):203-8. doi: 10.1006/bbrc.1993.2235.
Homeobox genes encode transcription factors involved in the process of normal development and differentiation of cells and organs. Recently, some homeobox genes are found implicated in hemato-lymphoid neoplasms. To assess the role of homeobox genes in normal development and neoplastic transformation of T-cells, we have surveyed for homeobox-containing gene expression in a human T-cell leukemia line with a polymerase chain reaction. Ten members of homeobox genes were isolated, including one novel sequence. The novel sequence was most related to mouse Cdx. One of the others, HOXB7, is expressed in most malignant T-cell lines and CD4-positive peripheral blood T-cells. Together with the recent observations, these results suggest that the protein products of these genes may participate in normal functions and/or transformation of T-cells.
同源框基因编码参与细胞和器官正常发育与分化过程的转录因子。最近，发现一些同源框基因与血液淋巴系统肿瘤有关。为了评估同源框基因在T细胞正常发育和肿瘤转化中的作用，我们用聚合酶链反应检测了人T细胞白血病细胞系中含同源框基因的表达情况。分离出了10个同源框基因成员，包括一个新序列。该新序列与小鼠Cdx最为相关。其中另一个基因HOXB7在大多数恶性T细胞系和CD4阳性外周血T细胞中表达。结合最近的观察结果，这些结果表明这些基因的蛋白质产物可能参与T细胞的正常功能和/或转化。
