Department of Urology, First Affiliated Hospital, School of Medicine, Zhejiang University, Qingchun Road 79, Hangzhou 310003, Zhejiang Province, China.
Phytomedicine. 2010 Apr;17(5):363-8. doi: 10.1016/j.phymed.2009.07.019. Epub 2009 Sep 11.
It is well known that the garlic-derived organosulfur compounds (OSCs) are effective to inhibit a variety of human cancers such as prostate, breast, colon, skin, lung, and bladder cancers. Herein, the pro-apoptotic effects of diallyl trisulfide (DATS), one of garlic-derived OSCs, on T24 bladder cancer cells were investigated. The results demonstrated that DATS suppressed proliferation of T24 bladder cancer cells in a dose- and time-dependent manner which was associated with induced G2/M Phase cell cycle arrest and apoptosis. Mechanistically, DATS inhibits phosphatidylinositol 3'-kinase/Akt activation that, in turn, results in modulation of Bcl-2 family proteins, leading to enhanced apoptosis of T24 cells. These findings suggest that DATS may be an effective way for treating human bladder and other types of cancers.
众所周知，大蒜衍生的有机硫化合物（OSCs）可有效抑制多种人类癌症，如前列腺癌、乳腺癌、结肠癌、皮肤癌、肺癌和膀胱癌。本文研究了大蒜衍生的 OSCs 之一二烯丙基三硫化物（DATS）对 T24 膀胱癌细胞的促凋亡作用。结果表明，DATS 呈剂量和时间依赖性抑制 T24 膀胱癌细胞的增殖，这与诱导的 G2/M 期细胞周期阻滞和细胞凋亡有关。从机制上讲，DATS 抑制了磷脂酰肌醇 3'-激酶/Akt 的激活，进而调节 Bcl-2 家族蛋白，导致 T24 细胞凋亡增强。这些发现表明，DATS 可能是治疗人类膀胱癌和其他类型癌症的有效方法。
