Chang Chung-Yu, Fang Yu-Ti, Tsai Shih-Meng, Chang Lin-Li, Yu Wen-Liang
Department of Microbiology, Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan.
Diagn Microbiol Infect Dis. 2009 Oct;65(2):214-6. doi: 10.1016/j.diagmicrobio.2009.06.005.
We surveyed the prevalence and contents of class 1 integrons in clinical Klebsiella pneumoniae isolates collected from Kaohsiung, Taiwan, during 2 periods (1993 and 2004). Class 1 integrons were present in 78 isolates (34.2%) from 1993 (n = 228) and 129 (32.9%) from 2004 (n = 392) and contained varied gene cassette number, type, and array. We found 2 atypical sul3-associated class 1 integrons and identified 26 different gene cassettes, including an aac(6')-Ib-cr cassette here firstly described in K. pneumoniae from Taiwan. The continuing evolution of class 1 integrons is threatening to undermine the effectiveness of antimicrobial therapy for K. pneumoniae.
我们调查了1993年和2004年两个时期从中国台湾高雄收集的临床肺炎克雷伯菌分离株中1类整合子的流行情况和内容。1993年（n = 228）的228株分离株中有78株（34.2%）存在1类整合子，2004年（n = 392）的392株分离株中有129株（32.9%）存在1类整合子，且其所含基因盒的数量、类型和排列各不相同。我们发现了2个非典型的与sul3相关的1类整合子，并鉴定出26种不同的基因盒，其中包括首次在来自台湾的肺炎克雷伯菌中描述的aac(6')-Ib-cr基因盒。1类整合子的持续进化可能会破坏肺炎克雷伯菌抗菌治疗的有效性。
