Department of Pharmaceutical Technology, University of Szeged, H-6720 Szeged, Eötvös u 6, Hungary.
Int J Pharm. 2010 Jan 4;383(1-2):132-7. doi: 10.1016/j.ijpharm.2009.09.013. Epub 2009 Sep 11.
Sucrose esters (SEs) are non-toxic, biodegradable, non-ionic surfactants. They have a wide range of hydrophilic-lipophilic balance values (1-16) and are usually applied as surfactants, or as solubility or penetration enhancers. The aims of this work were to study the gelling behaviour of SEs and the effects of this property on drug release. The gelling characteristics of two different SEs (P1670 and S970) were investigated by rheological measurements, and compared with each other. The effects of the gel-forming SEs on model drug (paracetamol) release were evaluated by in vitro drug release studies. The kinetics of the dissolution process were studied by analysing the dissolution data through the use of various kinetic equations. The results revealed that the gelling of the SEs is temperature- and concentration-dependent. The examined sucrose stearate (S970) has a stronger gel structure than that of sucrose palmitate (P1670) and this behaviour has a significant effect on the drug release. The analysis of the dissolution kinetic data in this study revealed that the dissolution follows the Korsmeyer-Peppas (paracetamol-P1670) or Higuchi (paracetamol-S970) equations.
蔗糖酯（SEs）是无毒、可生物降解的非离子型表面活性剂。它们具有广泛的亲水亲油平衡值（1-16），通常用作表面活性剂，或用作增溶或渗透增强剂。本工作旨在研究 SEs 的胶凝行为及其对药物释放的影响。通过流变学测量研究了两种不同 SE（P1670 和 S970）的胶凝特性，并对其进行了比较。通过体外药物释放研究评估了形成凝胶的 SE 对模型药物（扑热息痛）释放的影响。通过使用各种动力学方程分析溶解数据，研究了溶解过程的动力学。结果表明，SE 的胶凝作用是温度和浓度依赖性的。所研究的硬脂酸蔗糖酯（S970）的凝胶结构强于棕榈酸蔗糖酯（P1670），这种行为对药物释放有显著影响。本研究中溶解动力学数据的分析表明，溶解遵循 Korsmeyer-Peppas（扑热息痛-P1670）或 Higuchi（扑热息痛-S970）方程。
