Voronina T A, Garibova T L, Barch R, Rostock A, Khromova I V, Artemenko G N, Zigemund K, Hoffmann V
Farmakol Toksikol. 1990 May-Jun;53(3):52-4.
The comparative study of the psychotropic activity of new acyl derivatives of dibenzazepine and phenothiazine--bonnecor (chlorhydrate 3-carbethoxyamino-5(dimethylaminoacetyl) dibenzazepine and ethacizine (chlorhydrate 2-carbethoxyamino-10-(beta-diethyl-aminopropionyl)phenothiazine)--in the experiments on small laboratory animals showed the presence of the antidepressive, anxiolytic, antiamnesic and antihypoxic effects. The drugs exerted the psychotropic effects at administration in the doses exceeding those which influence the cardiovascular system. By the degree of the anxiolytic action bonnecor and ethacizine are inferior to diazepam, are as potent as trioxasine and are superior to meprobamat. The noted psychotropic action by its character and degree can serve as a beneficial supplement to the spectrum of the pharmacological activity of the studied compounds.
二苯并氮杂䓬和吩噻嗪新酰基衍生物——邦尼可（3 - 乙氧羰基氨基 - 5 -（二甲基氨基乙酰基）二苯并氮杂䓬盐酸盐）和乙卡嗪（2 - 乙氧羰基氨基 - 10 -（β - 二乙氨基丙酰基）吩噻嗪盐酸盐）——对小型实验动物的精神活性比较研究表明，它们具有抗抑郁、抗焦虑、抗遗忘和抗缺氧作用。这些药物在超过影响心血管系统剂量给药时发挥精神活性作用。就抗焦虑作用程度而言，邦尼可和乙卡嗪不如地西泮，与三恶嗪相当，优于甲丙氨酯。所指出的精神活性作用在性质和程度上可作为所研究化合物药理活性谱的有益补充。
