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[波尼可与α-氮杂环烷羧酸甲磺酸盐衍生物抗心律失常作用的比较研究]

[A comparative study of the antiarrhythmic action of bonnecor and the mesidide derivatives of alpha-azacycloalkane carboxylic acids].

作者信息

Paliani-Katsitadze N Sh, Berdiaev S Iu, Turilova A I, Kaverina N V, Likhosherstov A M

出版信息

Eksp Klin Farmakol. 1994 May-Jun;57(3):15-7.

PMID:8049618
Abstract

The antiarrhythmic properties of the dibenzazepine derivative bonnecor and derivatives of mesidides of alpha-azacycloalkanocarboxylic acids were studied in various experimental arrhythmia models. The comparative study revealed different antiarrhythmic effects in different arrhythmia models. Bonnecor was found to have a higher antiarrhythmic activity in most arrhythmic models. Tertiary salts were demonstrated to be more potent than quaternary ones.

摘要

在各种实验性心律失常模型中研究了二苯并氮杂卓衍生物邦尼可(bonnecor)和α-氮杂环烷羧酸甲磺酸盐衍生物的抗心律失常特性。比较研究揭示了在不同心律失常模型中不同的抗心律失常作用。发现在大多数心律失常模型中邦尼可具有更高的抗心律失常活性。已证明叔盐比季盐更有效。

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