Scopsi L, Ferrari C, Pilotti S, Holst J J, Rehfeld J F, Fossati G, Rilke F
Division of Pathological Anatomy and Cytology, Istituto Nazionale per lo Studio e la Cura dei Tumori, Milan, Italy.
Hum Pathol. 1990 Aug;21(8):820-30. doi: 10.1016/0046-8177(90)90051-6.
Thirty-three cases of histologically proven calcitonin-positive medullary thyroid carcinoma were studied immunocytochemically for the occurrence of prosomatostatin-related peptides. Positive cells, identified with a panel of antisera raised against four different regions of the prosomatostatin molecule, were found in 100% of the tumors. Most but not all somatostatin-positive cells were also immunoreactive for calcitonin. Notably, seven patients harboring somatostatin-rich tumors revealed a more favorable clinical course. The results (1) indicate that somatostatin production is a universal concomitant of thyroid medullary carcinoma, (2) suggest that these cells are likely to produce a somatostatin precursor molecule similar to mammalian prosomatostatin, and (3) imply that somatostatin-reactive cells may have as yet unknown roles in these tumors, possibly in the realm of paracrine and autocrine regulation of cell growth.
对33例经组织学证实的降钙素阳性甲状腺髓样癌进行了免疫细胞化学研究，以检测前生长抑素相关肽的存在情况。在100%的肿瘤中发现了用针对前生长抑素分子四个不同区域产生的一组抗血清鉴定出的阳性细胞。大多数但并非所有生长抑素阳性细胞也对降钙素呈免疫反应性。值得注意的是，7例患有富含生长抑素肿瘤的患者显示出更有利的临床病程。结果表明：（1）生长抑素的产生是甲状腺髓样癌普遍伴随的现象；（2）提示这些细胞可能产生一种类似于哺乳动物前生长抑素的生长抑素前体分子；（3）意味着生长抑素反应性细胞在这些肿瘤中可能具有尚未明确的作用，可能在细胞生长的旁分泌和自分泌调节领域。
