杜兴氏肌营养不良基因内基因重组频率的准确评估。
Accurate assessment of intragenic recombination frequency within the Duchenne muscular dystrophy gene.
作者信息
Abbs S, Roberts R G, Mathew C G, Bentley D R, Bobrow M
机构信息
Paediatric Research Unit, United Medical School Guy's Hospital, London, United Kingdom.
出版信息
Genomics. 1990 Aug;7(4):602-6. doi: 10.1016/0888-7543(90)90205-9.
PMID:1974880
Abstract
Polymorphic loci that lie at the two extremities of the Duchenne/Becker muscular dystrophy (DMD/BMD) gene have been used to estimate intragenic recombination rates. Multipoint linkage analysis of the CEPH panel of families suggests a total intragenic recombination frequency of nearly 0.12 (confidence intervals 0.041-0.226) over the genomic length of approximately 2 Mb.
摘要
位于杜氏/贝克氏肌肉营养不良症（DMD/BMD）基因两端的多态性位点已被用于估计基因内重组率。对CEPH家系面板进行的多点连锁分析表明，在大约2兆碱基的基因组长度上，基因内重组的总频率接近0.12（置信区间为0.041 - 0.226）。
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