Lukic A, Arsenijević N, Vujanić G, Ramić Z
School of Dental Medicine, University of Belgrade, Yugoslavia.
J Endod. 1990 Mar;16(3):119-22. doi: 10.1016/s0099-2399(06)81587-6.
Granuloma formation includes an immune response in oral tissues to various microorganisms and their products. The immunocompetent cells of both series (T and B) are present in the periapical lesions. In order to further analyze the relative contribution and pathophysiological significance of the T cell subsets in granuloma formation, we undertook the quantitative analysis of the CD3-positive, CD4-positive, CD8-positive and Ig-positive cells in these lesions by using indirect immunofluorescence. Evidence is provided showing predominance of T cells in diffuse and B cells in focal mononuclear infiltrates. CD8-positive cells were more frequent in diffuse infiltrates and in particular in granulomas with distinct epithelium while CD4-positive cells were more numerous in focal infiltrates. It appears that the presence and ratios of different subsets of immunocompetent cells reflects the pathogenesis of granuloma and transformation to cyst.
肉芽肿形成包括口腔组织对各种微生物及其产物的免疫反应。两个系列（T和B）的免疫活性细胞都存在于根尖周病变中。为了进一步分析T细胞亚群在肉芽肿形成中的相对作用和病理生理意义，我们采用间接免疫荧光法对这些病变中的CD3阳性、CD4阳性、CD8阳性和Ig阳性细胞进行了定量分析。结果表明，在弥漫性病变中T细胞占优势，而在局灶性单核浸润中B细胞占优势。CD8阳性细胞在弥漫性浸润中更常见，尤其是在有明显上皮的肉芽肿中，而CD4阳性细胞在局灶性浸润中更多见。不同免疫活性细胞亚群的存在和比例似乎反映了肉芽肿的发病机制以及向囊肿的转变。
