间皮瘤的风险与石棉和人造玻璃纤维的职业暴露：来自加拿大蒙特利尔的两项病例对照研究的证据。
Risk of mesothelioma and occupational exposure to asbestos and man-made vitreous fibers: evidence from two case-control studies in Montreal, Canada.
机构信息
INRS-Institut Armand-Frappier, Unit of Epidemiology and Biostatistics, Laval, Quebec, Canada.
出版信息
J Occup Environ Med. 2009 Oct;51(10):1177-84. doi: 10.1097/JOM.0b013e3181b68cef.
OBJECTIVE
To examine the effects of exposure to occupational asbestos and man-made vitreous fibers (MMVF) across a wide range of occupations on risk of mesothelioma.
METHODOLOGY
Two population-based case-control studies (1979-1986 and 1996-2001) provided 35 histologically confirmed mesothelioma cases and 1965 controls. A detailed job history was obtained to evaluate occupational exposure to many agents, including asbestos and MMVF.
RESULTS
The mesothelioma odds ratio for exposure to any asbestos type was 3.7 (95% confidence interval = 1.7 to 7.8). The subset exposed to amphibole fibers experienced an odds ratio = 7.0 (95% confidence interval = 2.7 to 18.5). Effects of MMVF could not be disentangled from those of asbestos.
DISCUSSION
In workers with exposure levels lower than in most historical cohort studies and across a wide range of industries, a strong association was found between asbestos, especially when it was amphibole, and mesothelioma.
目的
研究接触职业性石棉和人造玻璃纤维（MMVF）在广泛职业范围内对间皮瘤风险的影响。
方法
两项基于人群的病例对照研究（1979-1986 年和 1996-2001 年）提供了 35 例组织学证实的间皮瘤病例和 1965 名对照。获取了详细的职业史，以评估对许多制剂（包括石棉和 MMVF）的职业暴露。
结果
暴露于任何类型石棉的间皮瘤比值比为 3.7（95%置信区间= 1.7 至 7.8）。暴露于角闪石纤维亚组的比值比为 7.0（95%置信区间= 2.7 至 18.5）。无法将 MMVF 的作用与石棉的作用区分开来。
讨论
在接触水平低于大多数历史队列研究且在广泛的行业范围内的工人中，发现石棉（尤其是角闪石纤维）与间皮瘤之间存在很强的关联性。
Zotero 插件