Quyyumi A A
Cardiology Branch, National Heart, Lung, and Blood Institute, Bethesda, MD 20892.
Am Heart J. 1990 Sep;120(3):726-33. doi: 10.1016/0002-8703(90)90044-x.
Circadian rhythms have long been recognized to occur in many biologic phenomena, including secretion of hormones and activities of the autonomic nervous system. More recently, circadian rhythms have also been noted to occur in the incidences of certain cardiac and cerebrovascular events, including transient myocardial ischemia, myocardial infarction, sudden cardiac death, and stroke. The pathophysiology and the mechanisms underlying these variations are the focus of much investigation. The effects of different drug treatments on these circadian rhythms are also being studied. This information should enable better treatment strategies to be planned for patients who have either silent or symptomatic episodes of transient myocardial ischemia and potentially to prevent the occurrence of sudden, catastrophic cardiac events.
长期以来，人们已经认识到昼夜节律存在于许多生物现象中，包括激素分泌和自主神经系统的活动。最近，人们还注意到昼夜节律也出现在某些心脏和脑血管事件的发生率中，包括短暂性心肌缺血、心肌梗死、心源性猝死和中风。这些变化的病理生理学和潜在机制是许多研究的重点。不同药物治疗对这些昼夜节律的影响也在研究中。这些信息应有助于为有短暂性心肌缺血无症状或有症状发作的患者制定更好的治疗策略，并有可能预防突然发生的灾难性心脏事件。
