Buff D D, Calikyan R, Neches R B, Bavli S Z
Department of Medicine, St. John's Episcopal Hospital, Far Rockaway, NY 11691, USA.
Clin Cardiol. 1997 Mar;20(3):261-4. doi: 10.1002/clc.4960200314.
Circadian patterns of onset favoring the morning hours have been demonstrated for many cardiovascular disorders. Although much is known about cardiogenic acute pulmonary edema (CAPE), the relationship between time of day and CAPE episode onset has not been previously studied.
We examined 154 consecutive episodes of CAPE treated at an urban community hospital to determine whether circadian patterns existed in the time these episodes began.
For all episodes, a significant circadian pattern existed, with peak onset between 6:00 and 11:59 A.M. (p < 0.01). When CAPE episodes were analyzed by the most probable precipitant of pulmonary edema, only the pattern for patients with progressive symptoms, showing a peak in the 6:00 and 11:59 A.M. interval, was statistically significant (p < 0.01). Although a similar trend existed for CAPE occurring in association with acute myocardial infarction, the pattern fell short of statistical significance (p = 0.09).
These data suggest that circadian patterns favoring the morning hours exist for episodes of CAPE, and that patterns may vary depending on the precipitant of the episode.
许多心血管疾病已被证明发病的昼夜模式倾向于早晨时段。尽管关于心源性急性肺水肿（CAPE）已有很多了解，但此前尚未研究过一天中的时间与CAPE发作之间的关系。
我们检查了一家城市社区医院治疗的154例连续的CAPE发作病例，以确定这些发作开始的时间是否存在昼夜模式。
对于所有发作病例，存在显著的昼夜模式，发作高峰在上午6:00至11:59之间（p < 0.01）。当按肺水肿最可能的诱发因素对CAPE发作进行分析时，只有症状进行性加重的患者的模式在上午6:00至11:59之间出现高峰，具有统计学意义（p < 0.01）。尽管与急性心肌梗死相关的CAPE也存在类似趋势，但该模式未达到统计学意义（p = 0.09）。
这些数据表明，CAPE发作存在倾向于早晨时段的昼夜模式，并且模式可能因发作的诱发因素而异。
