Mills J L, Simpson J L, Rhoads G G, Graubard B I, Hoffman H, Conley M R, Lassman M, Cunningham G
National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892.
Lancet. 1990 Jul 14;336(8707):103-4. doi: 10.1016/0140-6736(90)91608-d.
In a case-control study to investigate whether women who use drugs to induce ovulation are at increased risk of conception of a child with a neural tube defect, 571 women who had a fetus or child with a neural tube defect, 546 women who had a fetus or child with other abnormalities, and 573 women who had an apparently normal fetus or child were questioned about infertility, fertility drug use, and related obstetric problems. The rate of maternal fertility drug use around the time of conception was not significantly higher for neural tube defects than for other abnormalities (odds ratio 1.28; 95% confidence interval 0.39, 4.51) or no abnormalities (odds ratio 0.80; 95% Cl 0.27, 2.27). Fertility drug use at any time was not significantly more frequent for neural tube defects than for other abnormalities (odds ratio 1.37; 95% Cl 0.70, 2.74) or no abnormalities (odds ratio 1.05; 95% Cl 0.56, 1.98).
在一项病例对照研究中，为调查使用药物诱导排卵的女性怀上神经管缺陷患儿的风险是否增加，研究人员询问了571名生育过神经管缺陷胎儿或患儿的女性、546名生育过其他异常胎儿或患儿的女性以及573名生育过明显正常胎儿或患儿的女性关于不孕、使用生育药物及相关产科问题的情况。受孕前后母体使用生育药物的比例，神经管缺陷组并不显著高于其他异常组（比值比1.28；95%置信区间0.39, 4.51）或无异常组（比值比0.80；95%置信区间0.27, 2.27）。在任何时候，神经管缺陷组使用生育药物的频率并不显著高于其他异常组（比值比1.37；95%置信区间0.70, 2.74）或无异常组（比值比1.05；95%置信区间0.56, 1.98）。
