Blatter B M, van der Star M, Roeleveld N
Department of Medical Informatics and Epidemiology, University of Nijmegen, The Netherlands.
Environ Health Perspect. 1994 Feb;102(2):140-5. doi: 10.1289/ehp.94102140.
We conducted a study of published work to evaluate the evidence for the hypothesis that environmental exposure and parental occupation are risk factors for neural tube defects. As other risk factors such as maternal illnesses, medication, and dietary factors have been reviewed before, this review only summarizes this information. In studies concerning environmental pollution, only a few weak associations were found. It appears that specific studies on the topic of parental occupation and neural tube defects are scarce. Therefore, studies on broader malformation categories, such as central nervous system defects, were also taken into account. Both maternal and paternal occupation seem to be associated with the occurrence of neural tube defects. However, results are not always consistent with each other, and relevant recommendations concerning prevention thus cannot be given before more studies with larger populations are conducted to confirm or refute the findings reviewed.
我们对已发表的研究进行了一项调查，以评估环境暴露和父母职业是神经管缺陷风险因素这一假设的证据。由于之前已对其他风险因素，如母亲疾病、药物和饮食因素进行了综述，本综述仅总结此信息。在有关环境污染的研究中，仅发现了一些微弱的关联。似乎关于父母职业与神经管缺陷这一主题的具体研究很少。因此，也考虑了关于更广泛畸形类别，如中枢神经系统缺陷的研究。母亲和父亲的职业似乎都与神经管缺陷的发生有关。然而，结果并不总是相互一致，因此在进行更多更大规模人群的研究以证实或反驳所综述的发现之前，无法给出有关预防的相关建议。
