Hugdahl Kenneth, Løberg Else-Marie, Nygård Merethe
Department of Biological and Medical Psychology, University of Bergen Bergen, Norway.
Front Neurosci. 2009 May 1;3(1):34-45. doi: 10.3389/neuro.01.001.2009. eCollection 2009 May.
In this article, we have reviewed recent findings from our laboratory, originally presented in Hugdahl et al. (2008). These findings reveal that auditory hallucinations in schizophrenia should best be conceptualized as internally generated speech mis-representations lateralized to the left superior temporal gyrus and sulcus, not cognitively suppressed due to enhanced attention to the 'voices' and failure of fronto-parietal executive control functions. An overview of diagnostic questionnaires for scoring of symptoms is presented together with a review of behavioral, structural, and functional MRI data. Functional imaging data have either shown increased or decreased activation depending on whether patients have been presented an external stimulus during scanning. Structural imaging data have shown reduction of grey matter density and volume in the same areas in the temporal lobe. We have proposed a model for the understanding of auditory hallucinations that trace the origin of auditory hallucinations to neuronal abnormality in the speech areas in the left temporal lobe, which is not suppressed by volitional cognitive control processes, due to dysfunctional fronto-parietal executive cortical networks.
在本文中，我们回顾了我们实验室的近期研究发现，这些发现最初发表于胡格达尔等人（2008年）的研究中。这些发现表明，精神分裂症中的幻听最好被概念化为向左颞上回和颞上沟侧化的内部产生的言语错误表征，并非由于对“声音”的关注度增强以及额顶叶执行控制功能失效而在认知上受到抑制。本文呈现了用于症状评分的诊断问卷概述，并对行为、结构和功能磁共振成像数据进行了综述。功能成像数据显示，根据患者在扫描过程中是否受到外部刺激，激活情况会有所增加或减少。结构成像数据显示，颞叶相同区域的灰质密度和体积有所减少。我们提出了一个理解幻听的模型，该模型将幻听的起源追溯到左颞叶言语区域的神经元异常，由于额顶叶执行皮质网络功能失调，这种异常未被意志性认知控制过程所抑制。
