Centre for Women's Health Research, Department of Obstetrics and Gynaecology and Monash Institute of Medical Research, Monash University, Melbourne, Victoria 3168, Australia.
Reproduction. 2009 Dec;138(6):883-93. doi: 10.1530/REP-09-0147. Epub 2009 Sep 15.
Angiogenesis, lymphangiogenesis and vascular maturation occur on a regular, physiological basis in human endometrium. These processes form part of a continuum of vascular remodelling involving numerous regulatory factors. Key factors include vascular endothelial growth factor (VEGF)A, VEGFC and VEGFD, and their associated receptors VEGFR1, VEGFR2 and VEGFR3. A second group of vascular regulatory proteins belongs to the angiopoietin (ANG)-TIE system. Although members of the VEGF family and the ANG-TIE system are represented in the endometrium, our understanding of how these different molecules interact to regulate remodelling of the blood and lymphatic vasculature present in the endometrium is still limited. A review of the current information is provided.
血管生成、淋巴管生成和血管成熟在人类子宫内膜中是基于正常的生理基础发生的。这些过程是涉及众多调节因子的血管重塑连续体的一部分。关键因素包括血管内皮生长因子（VEGF）A、VEGFC 和 VEGFD 及其相关受体 VEGFR1、VEGFR2 和 VEGFR3。第二组血管调节蛋白属于血管生成素（ANG）-TIE 系统。虽然 VEGF 家族和 ANG-TIE 系统的成员存在于子宫内膜中，但我们对于这些不同分子如何相互作用以调节存在于子宫内膜中的血液和淋巴管血管重塑的理解仍然有限。本文对现有信息进行了综述。
