Thurston Gavin
Regeneron Pharmaceuticals, 777 Old Saw Mill River Road, Tarrytown, NY 10591, USA.
Cell Tissue Res. 2003 Oct;314(1):61-8. doi: 10.1007/s00441-003-0749-6. Epub 2003 Aug 12.
This review focuses on the signaling system involving the Angiopoietin1/Tie2 receptor, which appears to be involved in the secondary stages of blood vessel formation. Although this system is crucial for blood and lymphatic vessel formation, identifying its precise role in embryonic and adult vascular biology has been a major challenge. The evidence for the key role of the Angiopoietin/Tie system is discussed, and some of the other members of the system (Ang2, Tie1) are mentioned. A comparison is made with the VEGF signaling system, which seems to provide a complementary, and somewhat more tractable, signaling system. Some of the basic unanswered questions concerning Tie/Angiopoietin biology and the secondary stages of blood vessel formation are also highlighted.
本综述聚焦于涉及血管生成素1/酪氨酸激酶受体2（Angiopoietin1/Tie2 receptor）的信号系统，该系统似乎参与血管形成的次级阶段。尽管此系统对血管和淋巴管形成至关重要，但确定其在胚胎及成体血管生物学中的精确作用一直是一项重大挑战。文中讨论了血管生成素/Tie系统关键作用的证据，并提及了该系统的其他一些成员（Ang2、Tie1）。同时与血管内皮生长因子（VEGF）信号系统进行了比较，后者似乎提供了一个互补且相对更易处理的信号系统。还强调了一些有关Tie/血管生成素生物学及血管形成次级阶段尚未解答的基本问题。
