Lavrik Inna N, Eils Roland, Fricker Nicolai, Pforr Carina, Krammer Peter H
Division of Immunogenetics, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.
Mol Biosyst. 2009 Oct;5(10):1105-11. doi: 10.1039/b905129p. Epub 2009 Aug 3.
Apoptosis is a process common to all multicellular organisms. Apoptosis leads to the elimination of cells via a complex but highly defined cellular programme. Defects in the regulation of apoptosis result in serious diseases such as cancer, autoimmunity, AIDS and neurodegeneration. Recently, a substantial step forward in understanding the complex apoptotic pathways has been made by utilising systems biology approaches. Systems biology combines rigorous mathematical modelling with experimental approaches in a closed loop cycle for advancing our knowledge about complex biological processes. In this review we describe the contemporary systems biology studies devoted to apoptotic signalling and focus on the question of how systems biology helps to understand life/death decisions made in the cell and to develop new approaches to rational treatment strategies.
细胞凋亡是所有多细胞生物共有的过程。细胞凋亡通过一个复杂但高度明确的细胞程序导致细胞的清除。细胞凋亡调控缺陷会导致严重疾病，如癌症、自身免疫性疾病、艾滋病和神经退行性疾病。最近，利用系统生物学方法在理解复杂的细胞凋亡途径方面取得了重大进展。系统生物学将严谨的数学建模与实验方法结合在一个闭环循环中，以增进我们对复杂生物过程的了解。在本综述中，我们描述了致力于细胞凋亡信号传导的当代系统生物学研究，并关注系统生物学如何帮助理解细胞中生死抉择以及开发合理治疗策略新方法的问题。
