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吲哚美辛对促肾上腺皮质激素分泌的刺激作用及外源性前列腺素的逆转作用。

Stimulation of ACTH secretion by indomethacin and reversal by exogenous prostaglandins.

作者信息

Hedge G A

出版信息

Prostaglandins. 1977 Jul;14(1):145-50. doi: 10.1016/0090-6980(77)90163-0.

DOI:10.1016/0090-6980(77)90163-0
PMID:197569
Abstract

The prostaglandin (PG) synthesis inhibitor, indomethacin, has been found to enhance adrenocorticotropin (ACTH) secretion upon injection directly into the anterior pituitary at a dose that is ineffective intravenously. Such stimulation was observed in combination with, and in the absence of, stimulation by a corticotropin-releasing factor (CRF) preparation. It was reversed to varying degrees by replacing certain PGs exogenously. It suggested that endogenous PGs in the anterior pituitary participate in the modulation of the sensitivity of this gland to the hypothalamic neurohormone, CRF.

摘要

前列腺素（PG）合成抑制剂吲哚美辛已被发现，当以静脉注射无效的剂量直接注入垂体前叶时，可增强促肾上腺皮质激素（ACTH）的分泌。这种刺激在促肾上腺皮质激素释放因子（CRF）制剂刺激存在和不存在的情况下均被观察到。通过外源性补充某些PG，这种刺激在不同程度上得到了逆转。这表明垂体前叶中的内源性PG参与了该腺体对下丘脑神经激素CRF敏感性的调节。

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引用本文的文献

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Endocrine. 2001 Nov;16(2):123-31. doi: 10.1385/ENDO:16:2:123.
2
Pharmacological studies of the involvement of hypothalamic prostaglandins in the regulation of thyrotropin secretion.下丘脑前列腺素参与促甲状腺激素分泌调节的药理学研究。
Environ Health Perspect. 1981 Apr;38:83-8. doi: 10.1289/ehp.813883.
3
Effect of prostaglandin E2 on ACTH and beta-endorphin release from rat adenohypophysis in vitro after secretagogues which can mimic various first or second messengers.
在体外，前列腺素E2对促肾上腺皮质激素（ACTH）和β-内啡肽从大鼠腺垂体释放的影响，这些促分泌素可模拟各种第一或第二信使。
Naunyn Schmiedebergs Arch Pharmacol. 1986 Jun;333(2):149-55. doi: 10.1007/BF00506518.
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The effect of indomethacin on the biochemical response to fracture stress in rats.吲哚美辛对大鼠骨折应激生化反应的影响。
Br J Exp Pathol. 1979 Dec;60(6):589-95.