Genchi C, Traldi P G, Bianciardi P P
University of Milan, Faculty of Veterinary Medicine, Via Celoria 10-20133, Milan, Italy.
Vet Ther. 2000 Spring;1(2):71-80.
In this study the efficacy of a 10% weight per volume solution of imidacloprid--registered as a flea control agent with the trademark Advantage topical solution--was assessed in Italy under field conditions in a total of 3272 dogs and cats. During the 4-week trial the number of fleas on each animal was assessed and lesions of flea allergy dermatitis (FAD; i.e., miliary or maculopapular dermatitis, hyperpigmentation, and crusty thickenings of the skin), alopecia, and pruritus were evaluated. Imidacloprid had a notable adulticidal effect and residual activity that controlled fleas and prevented reinfestation of treated animals for at least 4 weeks. In addition, a significant decrease of the clinical signs was documented regardless of each animal's breed, sex, body size, haircoat length, and living conditions. Some of the dogs were washed or shampooed after treatment without showing statistical differences in efficacy. This study demonstrates that a single treatment with imidacloprid is able to effectively control flea infestations in dogs and cats for at least 28 days and significantly contributes to the improvement or disappearance of clinical signs of FAD.
在本研究中，在意大利的野外条件下，对总共3272只犬猫评估了一种10%（重量/体积）吡虫啉溶液（注册为具有Advantage局部用溶液商标的跳蚤控制剂）的疗效。在为期4周的试验期间，评估了每只动物身上的跳蚤数量，并对跳蚤过敏性皮炎（FAD；即粟粒性或斑丘疹性皮炎、色素沉着和皮肤结痂增厚）、脱毛和瘙痒的病变进行了评估。吡虫啉具有显著的成虫杀灭作用和残留活性，可控制跳蚤并防止经治疗的动物再次感染至少4周。此外，无论每只动物的品种、性别、体型、被毛长度和生活条件如何，临床症状均有显著减轻。一些犬在治疗后被清洗或用洗发水洗澡，疗效无统计学差异。本研究表明，单次使用吡虫啉能够有效控制犬猫的跳蚤感染至少28天，并显著有助于改善或消除FAD的临床症状。
