Kimpton W G, Washington E A, Cahill R N
Department of Veterinary Preclinical Sciences, University of Melbourne, Parkville, Victoria, Australia.
Cell Immunol. 1990 Oct 1;130(1):236-43. doi: 10.1016/0008-8749(90)90178-t.
We report here the results of experiments in which the migration of three T cell subsets (CD4+, CD8+, and gamma delta+T19+ cells) through antigen-stimulated lymph nodes and subcutaneous granulomas has been compared with that through normal skin and resting lymph nodes. The percentage of gamma delta+T19+ lymphocytes was halved and the percentage of CD8+ lymphocytes was doubled in lymph draining stimulated compared with control tissues, and all lymphocyte subsets except gamma delta+T19+ lymphocytes had higher hourly outputs in lymph draining antigen-stimulated compared with control tissues. Antigen also resulted in a higher percentage of CD8+ lymphoblasts and a lower percentage of gamma delta+T19+ lymphoblasts in efferent lymph draining antigen-stimulated lymph nodes. The data indicate that lymphocyte subsets leave the blood with differing efficiencies in different vascular beds and raise the possibility that antigen can influence the rate at which tissues extract individual T cell subsets from the blood.
我们在此报告实验结果，该实验比较了三种T细胞亚群（CD4 +、CD8 +和γδ + T19 +细胞）通过抗原刺激的淋巴结和皮下肉芽肿的迁移情况，以及通过正常皮肤和静止淋巴结的迁移情况。与对照组织相比，在引流刺激组织的淋巴液中，γδ + T19 +淋巴细胞的百分比减半，CD8 +淋巴细胞的百分比翻倍，并且除γδ + T19 +淋巴细胞外，所有淋巴细胞亚群在引流抗原刺激组织的淋巴液中的每小时输出量均高于对照组织。抗原还导致在引流抗原刺激淋巴结的输出淋巴液中，CD8 +淋巴母细胞的百分比更高，而γδ + T19 +淋巴母细胞的百分比更低。数据表明淋巴细胞亚群在不同血管床中以不同效率离开血液，并增加了抗原可影响组织从血液中提取单个T细胞亚群速率的可能性。
