淋巴细胞亚群在血液以及外周淋巴结的输入淋巴管和输出淋巴管中的分布存在显著差异。
Lymphocyte subsets show marked differences in their distribution between blood and the afferent and efferent lymph of peripheral lymph nodes.
作者信息
Mackay C R, Kimpton W G, Brandon M R, Cahill R N
机构信息
Department of Veterinary Preclinical Sciences, University of Melbourne, Parkville, Victoria, Australia.
出版信息
J Exp Med. 1988 Jun 1;167(6):1755-65. doi: 10.1084/jem.167.6.1755.
The surface phenotypes (CD1, CD4, CD5, CD8, SBU-T19, MHC class I, MHC class II, and sIg) of cells in blood, lymph nodes, and lymph were determined to examine simultaneously the distribution of lymphocyte subsets circulating in blood, afferent lymph, and efferent lymph of a peripheral lymph node. Marked differences in the percentage of certain lymphocyte subsets were apparent within the compartments examined, suggesting that lymphocyte subsets leave the blood with differing efficiencies. Lymphocyte subsets also appeared to be extracted from the blood at different rates by lymph node as opposed to subcutaneous vascular endothelium. Endothelial cells in different vascular beds may express different numbers of molecules complementary to a set of migration-related cell surface molecules specific for each lymphocyte subset. Accordingly, the vascular endothelium would be the key factor in regulating nonrandom cell migration.
测定血液、淋巴结和淋巴中细胞的表面表型（CD1、CD4、CD5、CD8、SBU-T19、MHC I类、MHC II类和sIg），以同时检查外周淋巴结血液、输入淋巴和输出淋巴中循环淋巴细胞亚群的分布。在所检查的区室中，某些淋巴细胞亚群的百分比存在明显差异，这表明淋巴细胞亚群以不同效率离开血液。与皮下血管内皮相比，淋巴细胞亚群似乎也以不同速率被淋巴结从血液中提取。不同血管床中的内皮细胞可能表达不同数量的与每个淋巴细胞亚群特异的一组迁移相关细胞表面分子互补的分子。因此，血管内皮将是调节非随机细胞迁移的关键因素。
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