守护蛋白和蛋白磷酸酶2A：协同作用以维持染色体的连接
Shugoshin and PP2A: collaborating to keep chromosomes connected.
作者信息
Kateneva Anna V, Higgins Jonathan M G
机构信息
Division of Rheumatology, Immunology and Allergy, Brigham & Women's Hospital, Harvard Medical School, Smith Building Room 538A, 1 Jimmy Fund Way, Boston, MA 02115, USA.
出版信息
Dev Cell. 2009 Sep;17(3):303-5. doi: 10.1016/j.devcel.2009.08.016.
Timely release of sister chromatid cohesion is essential for accurate chromosome segregation during cell division. Shugoshin forms a complex with the phosphatase PP2A that has been proposed to dephosphorylate cohesin proteins to prevent premature loss of centromeric cohesion. A recent study in Molecular Cell by Xu et al. presents the structure of Shugoshin bound to PP2A and provides evidence that this interaction is required for cohesion protection.
及时释放姐妹染色单体黏连对于细胞分裂过程中染色体的准确分离至关重要。守护蛋白与磷酸酶PP2A形成复合物，有人提出该复合物可使黏连蛋白去磷酸化，以防止着丝粒黏连过早丧失。徐等人近期发表在《分子细胞》上的一项研究展示了与PP2A结合的守护蛋白的结构，并提供证据表明这种相互作用是黏连保护所必需的。
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