Ohlsson K, Olsson I
Scand J Haematol. 1977 Aug;19(2):145-52. doi: 10.1111/j.1600-0609.1977.tb02339.x.
Human granulocytes release 25-30% of the granular neutral proteases, collagenase and elastase, to the exterior of the cell during phagocytosis of yeast cells or immune complexes. Similar amounts of myeloperoxidase and lactoferrin are released. Crossed immunoelectrophoresis demonstrated that collagenase and elastase released extracellularly formed complexes with serum alpha1-antitrypsin. The presence of alpha1-antitrypsin complexes with granulocyte collagenase and elastase were also demonstrated in inflammatory processes, e.g. in the peritoneal exudate of acute peritonitis. The reactivity of neutrophil proteases with natural plasma protease inhibitors must be considered in assessing the role of these proteases as the etiologic agent of tissue damage and degradation during the inflammatory process.
在吞噬酵母细胞或免疫复合物的过程中，人类粒细胞会将25%-30%的颗粒性中性蛋白酶、胶原酶和弹性蛋白酶释放到细胞外。髓过氧化物酶和乳铁蛋白也会释放出相似的量。交叉免疫电泳显示，细胞外释放的胶原酶和弹性蛋白酶与血清α1-抗胰蛋白酶形成复合物。在炎症过程中，例如急性腹膜炎的腹腔渗出液中，也证实了α1-抗胰蛋白酶与粒细胞胶原酶和弹性蛋白酶形成的复合物的存在。在评估这些蛋白酶作为炎症过程中组织损伤和降解的病因时，必须考虑中性粒细胞蛋白酶与天然血浆蛋白酶抑制剂的反应性。
