在源自雄激素反应性小鼠乳腺肿瘤（狮王癌115）的自主亚系（千叶亚系2）中hst-1的获得性表达。
Acquired expression of hst-1 in an autonomous subline (Chiba subline 2) derived from androgen-responsive mouse mammary tumor (Shionogi carcinoma 115).
作者信息
Akakura K, Furuya Y, Sato N, Kodama T, Teshima S, Shimosato Y, Yoshida T, Terada M, Shimazaki J
机构信息
Department of Urology, School of Medicine, Chiba University.
出版信息
Jpn J Cancer Res. 1990 Jun-Jul;81(6-7):554-6. doi: 10.1111/j.1349-7006.1990.tb02606.x.
Abstract
Since growth of Shionogi Carcinoma 115 (SC 115) and its autonomous subline (CS 2) were regulated by fibroblast growth factor-like peptide, expression of int-2 and hst-1 was examined in these cell lines. Hybridization of genomic DNA with long terminal repeat of mouse mammary tumor virus (MMTV) revealed the same pattern of restriction fragments, showing the same integration of MMTV. Although weak expression of int-2 was noticed in the two cells, clear expression of hst-1 was seen only in CS 2 cultured with/without testosterone. It is suggested that autonomous growth of androgen-unresponsive CS 2 is connected with expression of hst-1.
摘要
由于静冈癌115（SC 115）及其自主亚系（CS 2）的生长受成纤维细胞生长因子样肽调控，因此检测了这些细胞系中int-2和hst-1的表达。用小鼠乳腺肿瘤病毒（MMTV）的长末端重复序列对基因组DNA进行杂交，结果显示了相同的限制性片段模式，表明MMTV的整合情况相同。虽然在这两种细胞中均检测到int-2的弱表达，但仅在添加/未添加睾酮培养的CS 2中观察到hst-1的明显表达。提示雄激素无反应性CS 2的自主生长与hst-1的表达有关。
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