Kanungo Suman, Paisley Allison, Lopez Anna Lena, Bhattacharya Mihir, Manna Byomkesh, Kim Deok Ryun, Han Seung Hyun, Attridge Stephen, Carbis Rodney, Rao Raman, Holmgren Jan, Clemens John D, Sur Dipika
National Institute of Cholera and Enteric Diseases, Kolkata, India.
Vaccine. 2009 Nov 16;27(49):6887-93. doi: 10.1016/j.vaccine.2009.09.008. Epub 2009 Sep 15.
Immune responses after one and two doses of the reformulated killed oral cholera vaccine were measured in a double-blind, randomized, placebo-controlled trial of 77 adults aged 18-40 years and 77 children aged 1-17 years residing in Kolkata, India. 65% of adults and 87% of children and 46% of adults and 82% of children exhibited a > or =4-fold rise in serum Vibrio cholerae O1 vibriocidal antibody titers from baseline following dose 1 and 2, respectively. Responses to V. cholerae O139 were less pronounced but followed a similar pattern. We demonstrate that in a cholera-endemic area, the vaccine elicited vibriocidal responses after a single-dose of the vaccine.
在一项针对居住在印度加尔各答的77名18至40岁成年人和77名1至17岁儿童的双盲、随机、安慰剂对照试验中，测量了一剂和两剂重新配制的口服霍乱灭活疫苗后的免疫反应。分别在第1剂和第2剂疫苗接种后，65%的成年人和87%的儿童以及46%的成年人和82%的儿童血清霍乱弧菌O1杀弧菌抗体滴度较基线水平有≥4倍的升高。对霍乱弧菌O139的反应不那么明显，但遵循类似模式。我们证明，在霍乱流行地区，单剂量疫苗即可引发杀弧菌反应。
