Woltering E A, O'Dorisio T M, Williams S T, Lebrado L, Fletcher W S
Department of Surgery, Oregon Health Sciences University, Portland 97201.
Metabolism. 1990 Sep;39(9 Suppl 2):176-9. doi: 10.1016/0026-0495(90)90240-d.
Somatostatin and its longer-acting analog, octreotide acetate, can be used effectively for the treatment of nonendocrine gastrointestinal disorders. Octreotide has been shown to decrease pancreatic fistula output by suppressing exocrine pancreatic function. We believe that octreotide acetate may be useful to prophylaxis against the development of pancreatic fistulas following pancreatic resection and may reduce the enzymatic and volume output of established pancreatic fistulas. We also have shown that administration of octreotide acetate 2 hours before a high carbohydrate test meal reduces gut peptide levels, which increase following meal ingestion in patients with the dumping syndrome. Reduction of circulating peptides in these patients may slow gut motility and improve glucose regulation, thus, providing relief of postvagotomy dumping symptoms.
生长抑素及其长效类似物醋酸奥曲肽可有效用于治疗非内分泌性胃肠道疾病。奥曲肽已被证明可通过抑制胰腺外分泌功能来减少胰瘘的排出量。我们认为醋酸奥曲肽可能有助于预防胰腺切除术后胰瘘的发生，并可能减少已形成的胰瘘的酶分泌量和排出量。我们还表明，在高碳水化合物试验餐进食前2小时给予醋酸奥曲肽可降低肠道肽水平，在倾倒综合征患者中，进食后肠道肽水平会升高。降低这些患者的循环肽水平可能会减慢肠道蠕动并改善血糖调节，从而缓解迷走神经切断术后的倾倒症状。
