Department of Pathophysiology, Medical School, University of Athens, Athens 11527, Greece.
Lupus. 2009 Oct;18(12):1096-9. doi: 10.1177/0961203309106763.
Autoimmune thyroid disease has been associated with several systemic autoimmune disorders. However, limited data are available regarding the prevalence and clinical associations of thyroid autoimmunity in antiphospholipid syndrome (APS). Seventy-five patients with APS, 75 patients with systemic lupus erythematosus (SLE) and 75 healthy controls were tested for the presence of antithyroid antibodies (ATAs) (anti-thyroglobulin and anti-thyroid peroxidase [anti-TPO]) using commercial ELISA. Clinical data were also recorded. Although no significant differences in the prevalence of ATAs were detected among APS, SLE patient groups and healthy controls, a significant increase of anti-TPO antibodies in patients with APS-SLE was found. An increased prevalence of ATAs in APS population with ischemic central nervous system (CNS) clinical manifestations was also detected. We present novel associations between thyroid autoimmunity and ischemic CNS clinical manifestations in the setting of APS.
自身免疫性甲状腺疾病与多种系统性自身免疫性疾病有关。然而，关于抗磷脂综合征（APS）中甲状腺自身免疫的患病率和临床关联的数据有限。使用商业 ELISA 检测了 75 例 APS 患者、75 例系统性红斑狼疮（SLE）患者和 75 名健康对照者的抗甲状腺抗体（ATAs）（抗甲状腺球蛋白和抗甲状腺过氧化物酶[抗 TPO]）。还记录了临床数据。尽管在 APS、SLE 患者组和健康对照组中未检测到 ATAs 患病率的显著差异，但发现 APS-SLE 患者的抗 TPO 抗体显著增加。还检测到 APS 人群中伴有缺血性中枢神经系统（CNS）临床表现的 ATAs 患病率增加。我们在 APS 背景下提出了甲状腺自身免疫与缺血性 CNS 临床表现之间的新关联。
