Versini Mathilde
Department of Internal Medicine, Archet-1 Hospital, University Hospital of Nice, Nice, France.
Front Endocrinol (Lausanne). 2017 Jul 21;8:175. doi: 10.3389/fendo.2017.00175. eCollection 2017.
Antiphospholipid syndrome (APS) is an autoimmune disease that manifests as recurrent venous or arterial thrombosis and/or pregnancy-related complications in the presence of persistent antiphospholipid (aPL) antibodies measured at least 3 months apart. APS occurs either as a primary condition or as a part of an underlying disorder, usually systemic lupus erythematosus (SLE). Otherwise, APS may be frequently associated with autoimmune disorders. Little is known about the association of APS and aPL antibodies with thyroid autoimmune diseases or thyroid autoantibodies. This is even more interesting that thyroid autoantibodies and aPL are both recognized causes of repeated miscarriages. Therefore, their combination is of particular importance in women of childbearing age. Several studies have pointed out an association between APS and thyroid autoimmunity, some of them suggesting common pathophysiologic processes and genetic background. A literature review was conducted on existing data on aPL/APS and thyroid autoimmune disorders, paying particular attention to the possible role of this association in obstetrical complications.
抗磷脂综合征（APS）是一种自身免疫性疾病，在至少间隔3个月检测到持续存在的抗磷脂（aPL）抗体时，表现为复发性静脉或动脉血栓形成和/或与妊娠相关的并发症。APS可作为原发性疾病出现，也可作为潜在疾病（通常是系统性红斑狼疮（SLE））的一部分出现。此外，APS可能经常与自身免疫性疾病相关。关于APS和aPL抗体与甲状腺自身免疫性疾病或甲状腺自身抗体之间的关联知之甚少。更有趣的是，甲状腺自身抗体和aPL都是反复流产的公认原因。因此，它们的组合在育龄妇女中尤为重要。几项研究指出了APS与甲状腺自身免疫之间的关联，其中一些研究表明存在共同的病理生理过程和遗传背景。对关于aPL/APS和甲状腺自身免疫性疾病的现有数据进行了文献综述，特别关注这种关联在产科并发症中的可能作用。
