2-(1,4-苯并二氧六环-2-基甲基)-6,7-二甲氧基-1,2,3,4-四氢异喹啉衍生物的合成及其α-肾上腺素能阻断活性
[Synthesis and alpha-adrenolytic activities of 2-(1,4-benzodioxan-2-yl- methyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline derivatives].
作者信息
Glusa E, Grüner H, Hagen A, Lohmann D, Foken H
机构信息
Institut für Pharmakologie der Medizinischen Akademie Erfurt.
出版信息
Pharmazie. 1990 Jun;45(6):408-10.
PMID:1976262
Abstract
The synthesis of the title compounds starting from 2-Chlormethylbenzdioxan and Tetrahydroisochinolines is presented. Their actions on the platelet aggregation and the inhibition of alpha-adrenoceptors at the isolated rabbit aorta and the vas deferens of the guinea pig were investigated.
摘要
本文介绍了从2-氯甲基苯并二恶烷和四氢异喹啉开始合成目标化合物的方法。研究了它们对兔血小板聚集的作用以及对离体兔主动脉和豚鼠输精管α-肾上腺素能受体的抑制作用。
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