Kandakai-Olukemi Y T, Dido M S
Department of Medical Microbiology, Faculty of Medical Sciences, University of Jos, P.M.B. 2084, Jos, Nigeria.
Ann Afr Med. 2009 Jan-Mar;8(1):10-3. doi: 10.4103/1596-3519.55757.
Antimicrobial resistance in Streptococcus pneumoniae has compromised the effectiveness of therapy for pneumococcal diseases and asymptomatic nasopharyngeal carriers play an important role in transmission of resistant strains.
Eighty-eight volunteer students attending 2 secondary schools in Jos, Nigeria were involved in this study to determine the antimicrobial resistant profile of Streptococcus pneumoniae isolated from the nasopharynx. The study population consisted of males and females between the ages of 15-25 years. Nasopharyngeal swab samples were analyzed for the presence of S. pneumoniae using standard bacteriological methods. The isolates were subjected to antimicrobial susceptibility testing using the disc diffusion method.
S. pneumoniae was isolated from 37 (42.04%) of the 88 samples. Isolates showed the highest resistance of 12 (32.43%) to erythromycin and lowest resistance of 4 (10.81%) to ciprofloxacin. The resistance profiles for the 26 (70.27%) penicillin-sensitive and 11 (29.72%) penicillin-resistant isolates were similar. Both exhibited varying degrees of resistance to several groups of antimicrobials. However, isolates found to be resistant to penicillin showed a higher degree of resistance to other antimicrobial agents.
This study has shown that some secondary school students are carriers of multiple antibiotic-resistant S. pneumoniae.
肺炎链球菌的抗菌耐药性削弱了肺炎球菌疾病治疗的有效性，无症状鼻咽携带者在耐药菌株传播中起重要作用。
88名就读于尼日利亚乔斯两所中学的志愿者学生参与了本研究，以确定从鼻咽部分离出的肺炎链球菌的抗菌耐药情况。研究人群包括年龄在15至25岁之间的男性和女性。使用标准细菌学方法分析鼻咽拭子样本中肺炎链球菌的存在情况。采用纸片扩散法对分离株进行抗菌药敏试验。
在88份样本中，有37份（42.04%）分离出肺炎链球菌。分离株对红霉素的耐药率最高，为12株（32.43%），对环丙沙星的耐药率最低，为4株（10.81%）。26株（70.27%）青霉素敏感株和11株（29.72%）青霉素耐药株的耐药情况相似。两者对几类抗菌药物均表现出不同程度的耐药性。然而，对青霉素耐药的分离株对其他抗菌药物的耐药程度更高。
本研究表明，一些中学生是多重耐药肺炎链球菌的携带者。
