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伊朗肺炎链球菌的血清型分布及抗生素敏感性模式

Serotype distribution and antibiotics susceptibility pattern of Streptococcus pneumonia in Iran.

作者信息

Habibian Samira, Mehrabi-Tavana Ali, Ahmadi Zyanab, Izadi Morteza, Jonaidi Nematolah, Darakhshanpoure Jalalodin, Salesi Mahmode, Zahraei Seyed Mohsen, Ataee Ramezan Ali

机构信息

Department of Medical Microbiology, Tonokabon Azad University of Medical Sciences, Tonokabon, IR Iran.

Health Management Research Center, Department of Medical Microbiology, Faculty of Medicine, Baqiyatallah University of Medical Sciences, Tehran, IR Iran.

出版信息

Iran Red Crescent Med J. 2013 Oct;15(10):e8053. doi: 10.5812/ircmj.8053. Epub 2013 Oct 5.

DOI:10.5812/ircmj.8053
PMID:24693373
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3950785/
Abstract

BACKGROUND

The development of antibiotic resistance among Streptococcus pneumoniae strains has caused significant health problems worldwide.

OBJECTIVES

The aim of this study was to determine antibiotic resistance pattern and serotypes distribution of Streptococcus pneumoniae strains isolated from clinical specimens.

MATERIAL AND METHODS

A total of fifty Streptococcus pneumoniae strains were isolated from Tehran Hospital's laboratory from 2008 to 2012. Antimicrobial susceptibility testing was performed using broth microdilution method and minimum inhibitory concentration (MIC) of each strain was determined. to verify the resistant strains and demonstrate the presence of antibiotic resistant genes, the PCR was performed.

RESULTS

The study showed that three strains (6%) and six strains (12%) indicated intermediate resistance and complete resistance to penicillin, respectively, 58% strains were susceptible to ceftazidime, two ones (4%) indicated resistance to ciprofloxacin, one (2%) indicated intermediate resistance to ceftriaxone , two strains (4%) indicated complete resistance and four (8%) strains indicated resistance to vancomycin.

CONCLUSIONS

The emergence of Streptococcus pneumoniae strains with multiple resistance needs permanent monitoring of antibiotic susceptibility patterns of clinical isolates. We have found that ceftazidime is not a suitable drug for choosing the treatment of pneumococcal infections.

摘要

背景

肺炎链球菌菌株中抗生素耐药性的发展在全球范围内引发了重大健康问题。

目的

本研究旨在确定从临床标本中分离出的肺炎链球菌菌株的抗生素耐药模式和血清型分布。

材料与方法

2008年至2012年期间，从德黑兰医院实验室共分离出50株肺炎链球菌菌株。采用肉汤微量稀释法进行药敏试验，并测定各菌株的最低抑菌浓度（MIC）。为了验证耐药菌株并证明抗生素耐药基因的存在，进行了聚合酶链反应（PCR）。

结果

研究表明，分别有3株（6%）和6株（12%）对青霉素呈中介耐药和完全耐药，58%的菌株对头孢他啶敏感，2株（4%）对环丙沙星耐药，1株（2%）对头孢曲松呈中介耐药，2株（4%）对万古霉素完全耐药，4株（8%）对万古霉素耐药。

结论

多重耐药肺炎链球菌菌株的出现需要对临床分离株的抗生素敏感性模式进行持续监测。我们发现头孢他啶不是治疗肺炎球菌感染的合适药物。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8544/3950785/f89554a2781b/ircmj-15-8053-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8544/3950785/f89554a2781b/ircmj-15-8053-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8544/3950785/f89554a2781b/ircmj-15-8053-g001.jpg

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Antimicrob Agents Chemother. 2012 Aug;56(8):4504-7. doi: 10.1128/AAC.06374-11. Epub 2012 May 29.
2
Laboratory-based diagnosis of pneumococcal pneumonia: state of the art and unmet needs.基于实验室的肺炎链球菌性肺炎诊断：现状与未满足的需求。
Clin Microbiol Infect. 2011 May;17 Suppl 3:1-13. doi: 10.1111/j.1469-0691.2011.03496.x.
3
Antimicrobial susceptibility pattern and serotyping of Streptococcus pneumoniae isolated from Kanti Children Hospital in Nepal.
Penicillin-Resistant trend of Streptococcus pneumoniae in Asia: A systematic review.
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Iran J Microbiol. 2014 Aug;6(4):198-210.
4
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Ann Clin Microbiol Antimicrob. 2014 Nov 11;13:53. doi: 10.1186/s12941-014-0053-1.
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Kathmandu Univ Med J (KUMJ). 2010 Apr-Jun;8(30):164-8. doi: 10.3126/kumj.v8i2.3551.
4
The spectrum of invasive pneumococcal disease at an adult tertiary care hospital in the early 21st century.21世纪初一家成人三级护理医院的侵袭性肺炎球菌病谱。
Medicine (Baltimore). 2010 Sep;89(5):331-336. doi: 10.1097/MD.0b013e3181f2b824.
5
Pneumococcal serotypes in children in 4 European countries.4 个欧洲国家儿童中的肺炎链球菌血清型。
Emerg Infect Dis. 2010 Sep;16(9):1428-39. doi: 10.3201/eid1609.100102.
6
Antimicrobial resistance of Streptococcus pneumoniae in Southeast Austria, 1997-2008.1997-2008 年奥地利东南部肺炎链球菌的耐药性研究。
Int J Antimicrob Agents. 2010 Jul;36(1):24-7. doi: 10.1016/j.ijantimicag.2010.03.001. Epub 2010 Apr 20.
7
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9
Acute bacterial meningitis caused by Streptococcus pneumoniae resistant to the antimicrobian agents and their serotypes.
Arq Neuropsiquiatr. 2008 Sep;66(3A):509-15. doi: 10.1590/s0004-282x2008000400014.
10
Antibiotic innovation may contribute to slowing the dissemination of multiresistant Streptococcus pneumoniae: the example of ketolides.抗生素创新可能有助于减缓多重耐药肺炎链球菌的传播：以酮内酯类药物为例。
PLoS One. 2008 May 7;3(5):e2089. doi: 10.1371/journal.pone.0002089.