Cerf M
Sem Hop. 1977 Jun 23;53(24):1457-61.
The digestive tract has a special immune system where predominate the secretory factors of IgA. The IgA secreted by the plasma cells of the digestive mucosa is dimeric and is poured into the intestinal lumen after being attached to a protein of epithelial orgin. These facts lead to defence reactions of a special type. The digestive consequences of a quantitative abnormality of this system (hypogammaglobulinemia) or qualitative abnormality such as alpha heavy chain disease or Whipple's disease, are briefly reviewed. The consequences of an abnormal response of this system are considered in the light of present knowledge concerning coeliac disease. On the whole, these recent studies should lead to a revision of the idea of digestive allergy.
消化道有一个特殊的免疫系统，其中占主导地位的是IgA的分泌因子。消化黏膜浆细胞分泌的IgA是二聚体，附着于上皮来源的蛋白质后被排入肠腔。这些事实引发了一种特殊类型的防御反应。本文简要回顾了该系统定量异常（低丙种球蛋白血症）或定性异常（如α重链病或惠普尔病）的消化后果。根据目前关于乳糜泻的知识，考虑了该系统异常反应的后果。总体而言，这些最新研究应会促使人们对消化过敏的观念进行修正。
