Department of Radiotherapy, Institut Curie, 75248 Paris, France.
World J Gastroenterol. 2009 Sep 21;15(35):4444-5. doi: 10.3748/wjg.15.4444.
Radiotherapy for locally advanced pancreatic cancer is technically difficult and frequently associated with high-grade digestive toxicity. Helical tomotherapy (HT) is a new irradiation modality that combines megavoltage computed tomography imaging for patient positioning with intensity-modulated fan-beam radiotherapy. Its recent availability opens new fields of exploration for pancreatic radiotherapy as a result of its ability to tailor very well-defined dose distributions around the target volumes. Here, we report the use of HT in two patients with locally advanced pancreatic cancer. Doses to the bowel, kidneys and liver were reduced significantly, which allowed for excellent treatment tolerance without any high-grade adverse effects in either patient.
局部晚期胰腺癌的放射治疗技术难度大，常伴有高级别消化道毒性。螺旋断层放疗（HT）是一种新的放疗方式，它将兆伏级计算机断层成像技术用于患者定位与强度调制扇形束放疗相结合。由于其能够很好地为靶区定制非常明确的剂量分布，因此它的出现为胰腺癌放疗开辟了新的探索领域。在此，我们报告了 2 例局部晚期胰腺癌患者使用 HT 的情况。肠、肾和肝的剂量显著降低，在这 2 例患者中均未出现任何高级别不良反应，治疗耐受性良好。
