No rearrangement of c-mos in salivary gland pleomorphic adenomas with 8q12 aberrations.
作者信息
Rommel B, Bullerdiek J, Bartnitzke S, Schloot W
机构信息
Centre of Human Genetics, University of Bremen, F.R.G.
出版信息
Cancer Genet Cytogenet. 1990 Oct 15;49(2):165-9. doi: 10.1016/0165-4608(90)90138-z.
PMID:1976432
Abstract
The frequent occurrence of salivary gland pleomorphic adenomas characterized by clonal structural chromosome abnormalities involving 8q12 raises the question as to how the cytogenetic rearrangements correspond to molecular mechanisms of tumor development. Since the proto-oncogene c-mos maps to this breakpoint region, DNA from eight adenomas with these aberrations was isolated and checked for rearrangements of c-mos after digestion by BamHI, EcoRI and HindIII. In none of the tumors was a rearranged allele besides the germ-line fragments found.
摘要
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