Chang Shyang, Chang Zhe-Gung, Li Shiun-Jeng, Chiang Meng-Ju, Ma Chia-Mei, Cheng Hsiu-Yao, Hsieh Sheng-Hwu
Department of Electrical Engineering, National Tsing Hua University, Hsinchu 300, Taiwan, ROC.
Chin J Physiol. 2009 Feb 28;52(1):1-7. doi: 10.4077/cjp.2009.amg070.
The aim of this study was to investigate if there were any effects on the electroencephalogram (EEG) of human brain by the manual stimulation of Neiguan (PC 6) acupuncture site. In this paper, two groups of six healthy male volunteers of ages 27.6 +/- 14.2 (mean +/- SD) and 28.5 +/- 13.0 (mean +/- SD) and no neurological disease participated in this study. A digital storage of 12-channel EEG recorder was used and spectral analyses of the data set of 18 trials were obtained before, during, and after sham/ manual acupuncture. To minimize artefacts, all data were collected with the subjects alert but eyes closed. No significant changes (P > 0.05) were obtained for the sham acupuncture group. As for the manual acupuncture group, the needle was inserted perpendicularly into the PC 6 acupuncture site and manually stimulated about 15 to 30 seconds to achieve De Qi sensation. Needles were left in place for 30 min and then removed. Analysis of the EEG data due to acupuncture was compared to the baseline data and changes were obtained. First, all trials had an increase in the amplitude and power of the alpha band during manual acupuncture (P < 0.05) when compared with the baseline data. Secondly, in the mean time, the frequency peaks in alpha band of 12-channels were all synchronized with much smaller standard deviation (P < 0.01). Thirdly, the manual acupuncture effects of higher power and synchronized frequencies persisted for at least 10 minutes after the experiment (P < 0.05) and did not disappear immediately for all 18 experiments. Finally, we hypothesized that the higher power and synchronized rhythms in brain oscillations may have to do with autonomic nervous system.
本研究旨在探讨手动刺激内关穴（PC 6）对人脑脑电图（EEG）是否有任何影响。本文中，两组年龄分别为27.6±14.2（均值±标准差）和28.5±13.0（均值±标准差）且无神经疾病的六名健康男性志愿者参与了本研究。使用数字存储的12通道脑电图记录仪，并在假针刺/手动针刺前、针刺期间和针刺后获得18次试验数据集的频谱分析。为了尽量减少伪迹，所有数据均在受试者清醒但闭眼的状态下收集。假针刺组未获得显著变化（P>0.05）。对于手动针刺组，将针垂直插入PC 6穴位，并手动刺激约15至30秒以获得得气感。针留置30分钟后取出。将针刺引起的脑电图数据分析与基线数据进行比较，并获得变化情况。首先，与基线数据相比，所有试验在手动针刺期间α波段的幅度和功率均增加（P<0.05）。其次，与此同时，12通道α波段的频率峰值全部同步，标准差小得多（P<0.01）。第三，较高功率和同步频率的手动针刺效应在实验后至少持续10分钟（P<0.05），并且在所有18次实验中并非立即消失。最后，我们假设脑振荡中较高的功率和同步节律可能与自主神经系统有关。
