Chang Shyang, Chao Wei-Lun, Chiang Meng-Ju, Li Shiun-Jeng, Lu Yu-Tsung, Ma Chia-Mei, Cheng Hsiu-Yao, Hsieh Sheng-Hwu
Department of Electrical Engineering, National Tsing Hua University, Hsinchu, Taiwan, ROC.
Chin J Physiol. 2008 Jun 30;51(3):167-77.
The aims of this study were to investigate (i) if and when the blood pressure would rise or fall and (ii) the associated changes of human heart rate variability (HRV) by manual stimulation of the Neiguan (PC 6) acupuncture site. In this paper, two groups of six healthy male volunteers with ranges of ages 20-56 and 20-55 and with no neurological diseases participated in this study. In order to minimize artefacts, the electrocardiogram (ECG) and radial arterial pulse pressure wave were collected with the subjects alert but eyes closed before, during, and after sham/manual acupuncture. No statistically significant changes (P > 0.05) were found in the sham acupuncture group. As for the manual acupuncture group, the needle was inserted into the PC 6 acupoint and manually stimulated about 15 to 30 seconds to achieve De Qi sensation. Needles were left in place for 30 min and then removed. Analysis of the data due to acupuncture was then compared with the baseline values. Results indicate that the blood pressures of different subject can either rise (P < 0.01) or fall (P < 0.01). To further determine the indicator for one subject who exhibited both rise and fall of blood pressures, 7 more trials were given conducted with the same protocol until statistically significant results were obtained (P < 0.01). We found that his change of blood pressure was highly correlated (p = -0.94 and -0.99 for rise and fall, respectively) with the ratio of the magnitude of pulse pressure to that of the dicrotic notch in the local radial pulse wave (P < 0.01). As to the heart rate variability (HRV) spectra, significant changes in the low frequency (LF) and very low frequency (VLF) ranges were also detected. These results indicate that the autonomic innervations of heart have been modified. However, the information on the power of LF, high frequency (HF), and LF/HF of HRV are not conclusive to statistically differentiate the sympathetic contribution from that of the parasympathetic nervous systems at present stage.
（i）血压是否以及何时会升高或降低；（ii）通过手动刺激内关穴（PC 6）引起的人体心率变异性（HRV）的相关变化。在本文中，两组年龄范围分别为20 - 56岁和20 - 55岁且无神经疾病的六名健康男性志愿者参与了本研究。为了将伪迹降至最低，在假针刺/手动针刺之前、期间和之后，让受试者保持清醒但闭眼，同时采集心电图（ECG）和桡动脉脉搏压力波。在假针刺组中未发现统计学上的显著变化（P > 0.05）。对于手动针刺组，将针插入PC 6穴位并手动刺激约15至30秒以获得得气感。针留置30分钟后取出。然后将针刺引起的数据与基线值进行比较。结果表明，不同受试者的血压可能升高（P < 0.01）或降低（P < 0.01）。为了进一步确定一名血压既有升高又有降低的受试者的指标，按照相同方案又进行了7次试验，直至获得统计学上的显著结果（P < 0.01）。我们发现，他的血压变化与局部桡动脉脉搏波中脉压与重搏波切迹幅度的比值高度相关（升高和降低时的p值分别为 - 0.94和 - 0.99，P < 0.01）。至于心率变异性（HRV）频谱，在低频（LF）和极低频（VLF）范围内也检测到了显著变化。这些结果表明心脏的自主神经支配已被改变。然而，目前阶段关于HRV的低频（LF）、高频（HF）功率以及LF/HF的信息在统计学上还不能确凿地区分交感神经和副交感神经系统的贡献。
