Mshelia D S, Buratai L B, Mamza Y P
Department of Chemical Pathology, University of Maiduguri, NIgeria.
Niger J Clin Pract. 2009 Jun;12(2):173-8.
BACKGROUND/OBJECTIVES: Cardiovascular disease is a major cause of morbidity and mortality among patients with chronic kidney disease, and accounts for 50% of all deaths in them. Dyslipidaemia does not only accelerate atherosclerosis in these patients but also progresses the renal disease. This study therefore set to investigate the pattern of lipid profile in pre-dialysis chronic kidney disease patients.
This was case control study of 63 pre-dialysis chronic kidney disease patients attending University of Maiduguri teaching Hospital and 60 control subjects. All factors that may lead to dyslipidaemia were excluded in all subjects except hypertension. Lipid profiles were measured by standard methods. Data were analyzed using a statistical software SPSS version 11.0. Their observed differences in mean-SEM values were analyzed for statistical significance using Student's t-test andp-value <0.05 was considered significant.
the mean+SEM of total cholesterol 4.50+0.14 mmol/L and triglycerides 2.18+0.10 mmol/L in patients were significantly higher than that of the controls 3.79+0.11 mmol/L and 1.19+0.06 mmol/L respectively, p<0.05. Similarly the mean+SEM of LDL 2.62+0.16 mmol/L and LDL/HDL ratio 3.53+0.12 in patients were significantly higher when compared to that of the controls 2.04+0.16 mmol/L and 2.04+0.08 respectively, p<0.05. However, although the mean+SEM HDL in patient 1.07+0.07 mmol/L, was lower than that of the controls 1.21+0.06 mmol/L, the difference was not statistically significant, p>0.05. The pattern of lipid profile did not change with severity of disease and dyslipidaemia in patients were more in triglycerides, 68.3% and HDL, 63.5% than in TC, 22.2% and LDL, 17.5%.
Dyslipidaemia is common in pre-dialysis chronic kidney disease patients. It is pertinent to investigate and treat dyslipidaemia early in the course of the disease as it may prevent further progression of the renal damage.
背景/目的：心血管疾病是慢性肾脏病患者发病和死亡的主要原因，占其所有死亡病例的50%。血脂异常不仅会加速这些患者的动脉粥样硬化，还会使肾脏疾病进展。因此，本研究旨在调查透析前慢性肾脏病患者的血脂谱模式。
这是一项病例对照研究，研究对象为63名在迈杜古里大学教学医院就诊的透析前慢性肾脏病患者和60名对照者。除高血压外，所有可能导致血脂异常的因素均在所有研究对象中被排除。血脂谱采用标准方法测量。数据使用统计软件SPSS 11.0进行分析。使用学生t检验分析他们观察到的均值-标准误差异的统计学意义，p值<0.05被认为具有统计学意义。
患者的总胆固醇均值+标准误为4.50+0.14 mmol/L，甘油三酯均值+标准误为2.18+0.10 mmol/L，显著高于对照组的3.79+0.11 mmol/L和1.19+0.06 mmol/L（p<0.05）。同样，患者的低密度脂蛋白均值+标准误为2.62+0.16 mmol/L，低密度脂蛋白/高密度脂蛋白比值均值+标准误为3.53+0.12，与对照组的2.04+0.16 mmol/L和2.04+0.08相比，显著更高（p<0.05）。然而，尽管患者的高密度脂蛋白均值+标准误为1.07+0.07 mmol/L，低于对照组的1.21+0.06 mmol/L，但差异无统计学意义（p>0.05）。血脂谱模式并未随疾病严重程度而改变，患者中血脂异常更多见于甘油三酯（68.3%）和高密度脂蛋白（63.5%），而非总胆固醇（22.2%）和低密度脂蛋白（17.5%）。
血脂异常在透析前慢性肾脏病患者中很常见。在疾病过程中早期调查和治疗血脂异常很有必要，因为这可能预防肾脏损害的进一步进展。
