Department of Pediatric Endocrinology, Endocrine and Metabolism Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
Pediatr Diabetes. 2010 Mar;11(2):101-6. doi: 10.1111/j.1399-5448.2009.00534.x. Epub 2009 Sep 18.
Type 2 diabetes mellitus (T2DM) and impaired fasting glucose (IFG) are increasing in young population who are facing an escalating trend of overweight. The aim of this study was to determine the prevalence of IFG and T2DM for the first time in a population-based sample of Iranian obese children.
This cross-sectional, population-based study was conducted in Isfahan, the second large city of Iran. Overall, 672 overweight and obese school students, selected from 7554 students, aged 6-19 yr, were screened for IFG and T2DM. Fasting plasma glucose (FPG) and lipid profile were measured in all participants. Oral glucose tolerance test and insulin level were measured in those children with IFG. Insulin resistance was defined as homeostasis model assessment for insulin resistance (HOMA-IR) > 3.10.
Among the7554 students (48.7% boys and 51.3% girls) studied, 9.34% (n = 706) were overweight and 5.3% (n = 403) were obese. A number of 672 overweight and obese students including 302 (44.9%) boys and 370 (55.1%) girls, with a mean age of 12.8 +/- 3.10 yr underwent biochemical work up. Overall, the prevalence of IFG was 4.61% (n = 31), the corresponding figure was 2% (n = 4) in the 6-10 yr age group, and 5% (n = 27) in those aged 10.1-19 yr. The prevalence of T2DM was 0.1% (n = 1; age, 18.00 yr). Impaired glucose tolerance and insulin resistance were detected in three and six participants with IFG, who consisted 0.4 and 0.8% of total obese and overweight students, respectively.
Although the prevalence of T2DM is low in Iranian obese children, IFG is not uncommon. Preventive measures and screening of FPG should be considered for these children.
2 型糖尿病（T2DM）和空腹血糖受损（IFG）在面临超重比例不断上升的年轻人群中越来越常见。本研究的目的是首次在伊朗肥胖儿童的人群样本中确定 IFG 和 T2DM 的流行率。
本横断面、基于人群的研究在伊朗第二大城市伊斯法罕进行。总体而言，从 7554 名学生中选择了 672 名超重和肥胖的学龄儿童，筛查 IFG 和 T2DM。所有参与者均测量空腹血糖（FPG）和血脂谱。对 IFG 患儿进行口服葡萄糖耐量试验和胰岛素水平测定。胰岛素抵抗定义为稳态模型评估的胰岛素抵抗（HOMA-IR）>3.10。
在所研究的 7554 名学生（48.7%为男生，51.3%为女生）中，9.34%（n=706）为超重，5.3%（n=403）为肥胖。共有 672 名超重和肥胖学生（包括 302 名男生和 370 名女生），平均年龄为 12.8±3.10 岁，进行了生化检查。总体而言，IFG 的患病率为 4.61%（n=31），6-10 岁年龄组的相应数字为 2%（n=4），10.1-19 岁年龄组为 5%（n=27）。T2DM 的患病率为 0.1%（n=1；年龄为 18.00 岁）。在 IFG 患者中，有 3 名和 6 名患者分别检出葡萄糖耐量受损和胰岛素抵抗，分别占肥胖和超重学生总数的 0.4%和 0.8%。
尽管伊朗肥胖儿童 T2DM 的患病率较低，但 IFG 并不少见。应考虑对这些儿童进行空腹血糖预防性措施和筛查。
