Guerrero-Romero Fernando, Violante Rafael, Rodríguez-Morán Martha
Biomedical Research Unit of the Mexican Social Security Institute (MSSI), Támpico, Mexico.
Paediatr Perinat Epidemiol. 2009 Jul;23(4):363-9. doi: 10.1111/j.1365-3016.2009.01035.x.
Published data on the distribution of fasting plasma glucose (FPG) in children are scarce. We therefore set out to examine the distribution of FPG and determine the prevalence of impaired fasting glucose (IFG), impaired glucose tolerance (IGT) and type 2 diabetes (T2-DM) in Mexican children aged 6-18 years in a community-based cross-sectional study. A total of 1534 apparently healthy children were randomly enrolled and underwent an oral glucose tolerance test. IFG was defined by an FPG value between >or=100 and <126 mg/dL, IGT by glucose concentration 2-h post-load between >or=140 and <200 mg/dL, and T2-DM by glucose concentration 2-h post-load >or=200 mg/dL. The FPG level at the 75(th) percentile of distribution was 98.0, 100.0 and 99.0 mg/dL for children aged 6-9, 10-14 and 15-18 years, respectively; the 95(th) percentile of FPG was greater than 100 mg/dL for all the age strata. In the population overall, the prevalences of IFG, IGT, and T2-DM were 18.3%, 5.2% and 0.6%, respectively. Among obese children and adolescents, the prevalences of IFG, IGT, IFG + IGT and T2-DM were 19.1%, 5.7%, 2.5% and 1.3%. Our study shows a high prevalence of prediabetes and is the first that reports the distribution of FPG in Mexican children and adolescents.
关于儿童空腹血糖（FPG）分布的已发表数据很少。因此，我们开展了一项基于社区的横断面研究，以调查墨西哥6至18岁儿童的FPG分布情况，并确定空腹血糖受损（IFG）、糖耐量受损（IGT）和2型糖尿病（T2-DM）的患病率。总共随机招募了1534名表面健康的儿童，并让他们接受口服葡萄糖耐量测试。IFG的定义为FPG值在≥100且<126mg/dL之间，IGT为负荷后2小时血糖浓度在≥140且<200mg/dL之间，T2-DM为负荷后2小时血糖浓度≥200mg/dL。6至9岁、10至14岁和15至18岁儿童FPG分布的第75百分位数分别为98.0、100.0和99.0mg/dL；所有年龄组FPG的第95百分位数均大于100mg/dL。在总体人群中，IFG、IGT和T2-DM的患病率分别为18.3%、5.2%和0.6%。在肥胖儿童和青少年中，IFG、IGT、IFG+IGT和T2-DM的患病率分别为19.1%、5.7%、2.5%和1.3%。我们的研究显示糖尿病前期患病率很高，并且是第一项报告墨西哥儿童和青少年FPG分布情况的研究。
