Carvalho C, Ferreira I, Gaião S, Guimarães S, Costa R, Santos J, Sampaio S, Bustorff M, Oliveira G, Pestana M
Nephrology, Research and Development Unit, School of Medicine, University of Porto, Porto, Portugal.
Transpl Infect Dis. 2010 Apr;12(2):151-4. doi: 10.1111/j.1399-3062.2009.00456.x. Epub 2009 Sep 17.
Coccidioidomycosis is a fungal infection caused by Coccidioides species endemic to the desert south western United States. In healthy people, manifestations range mainly from asymptomatic to mild influenza-like syndrome. In immunosuppressed patients, extrapulmonary dissemination is common. We report the case of a patient with a parenchymal central nervous system lesion. This presentation is considered very rare. The highest risk of infection after solid organ transplantation occurs during the first year. Risk factors include treatment of acute rejection. In the reported case, the infection was probably donor-derived, as our patient had no history of traveling to endemic areas. Mortality is high among transplanted recipients with coccidioidomycosis, particularly those with disseminated infection.
球孢子菌病是一种由球孢子菌属引起的真菌感染，该菌在美国西南部沙漠地区流行。在健康人群中，表现主要从无症状到轻度流感样综合征。在免疫抑制患者中，肺外播散很常见。我们报告了一例患有实质性中枢神经系统病变的患者。这种表现被认为非常罕见。实体器官移植后感染的最高风险发生在第一年。危险因素包括急性排斥反应的治疗。在报告的病例中，感染可能源自供体，因为我们的患者没有前往流行地区的病史。患有球孢子菌病的移植受者死亡率很高，尤其是那些有播散性感染的患者。
