van Leeuwen E, Repping S, Prins J M, Reiss P, van der Veen F
Centre for Reproductive Medicine, Department of Obstetrics and Gynaecology, Academic Medical Centre, Amsterdam, the Netherlands.
Neth J Med. 2009 Sep;67(8):322-7.
For HIV -1-infected men and women the introduction of highly active antiretroviral therapy (HART) in 1996 led to a spectacular increase in life expectancy and quality of life. In Western society where HART is readily available, HIV -1 is now considered to be a chronic disease and as a consequence quality of life is an important aspect for men and women with HIV-1. Many of them express the desire to father or mother a child. Assisted reproductive technologies, including intrauterine insemination (IUI), in vitro fertilisation (IVF) and intracytoplasmatic sperm injection (ICSI) in combination with semen washing have been used to decrease the risk of HIV -1 transmission in HIV-1-infected discordant couples with an HIV-1-infected man. This article aims to summarise the current state of the art of assisted reproductive technologies for couples with an HIV -1-infected man and to discuss current trends and dilemmas in the treatment of these couples.
对于感染了人类免疫缺陷病毒1型（HIV -1）的男性和女性而言，1996年高效抗逆转录病毒疗法（HART）的引入使预期寿命和生活质量显著提高。在HART容易获得的西方社会，HIV -1现在被视为一种慢性病，因此生活质量对于感染HIV -1的男性和女性来说是一个重要方面。他们中的许多人表达了生育子女的愿望。辅助生殖技术，包括宫内人工授精（IUI）、体外受精（IVF）以及卵胞浆内单精子注射（ICSI）并结合精液清洗，已被用于降低HIV -1感染的男性与未感染HIV -1的配偶组成的不一致伴侣之间HIV -1传播的风险。本文旨在总结针对男性感染HIV -1的伴侣的辅助生殖技术的当前技术水平，并讨论治疗这些伴侣时的当前趋势和困境。
