位于8号染色体长臂24区的多个基因座与前列腺癌易感性相关。
Multiple loci on 8q24 associated with prostate cancer susceptibility.
作者信息
Al Olama Ali Amin, Kote-Jarai Zsofia, Giles Graham G, Guy Michelle, Morrison Jonathan, Severi Gianluca, Leongamornlert Daniel A, Tymrakiewicz Malgorzata, Jhavar Sameer, Saunders Ed, Hopper John L, Southey Melissa C, Muir Kenneth R, English Dallas R, Dearnaley David P, Ardern-Jones Audrey T, Hall Amanda L, O'Brien Lynne T, Wilkinson Rosemary A, Sawyer Emma, Lophatananon Artitaya, Horwich Alan, Huddart Robert A, Khoo Vincent S, Parker Christopher C, Woodhouse Christopher J, Thompson Alan, Christmas Tim, Ogden Chris, Cooper Colin, Donovan Jenny L, Hamdy Freddie C, Neal David E, Eeles Rosalind A, Easton Douglas F
机构信息
Cancer Research UK Genetic Epidemiology Unit, University of Cambridge, Cambridge, UK.
出版信息
Nat Genet. 2009 Oct;41(10):1058-60. doi: 10.1038/ng.452. Epub 2009 Sep 20.
Previous studies have identified multiple loci on 8q24 associated with prostate cancer risk. We performed a comprehensive analysis of SNP associations across 8q24 by genotyping tag SNPs in 5,504 prostate cancer cases and 5,834 controls. We confirmed associations at three previously reported loci and identified additional loci in two other linkage disequilibrium blocks (rs1006908: per-allele OR = 0.87, P = 7.9 x 10(-8); rs620861: OR = 0.90, P = 4.8 x 10(-8)). Eight SNPs in five linkage disequilibrium blocks were independently associated with prostate cancer susceptibility.
先前的研究已确定8号染色体长臂24区（8q24）上的多个位点与前列腺癌风险相关。我们通过对5504例前列腺癌病例和5834例对照进行标签单核苷酸多态性（SNP）基因分型，对8q24上的SNP关联进行了全面分析。我们证实了三个先前报道位点的关联性，并在另外两个连锁不平衡区域确定了其他位点（rs1006908：等位基因比数比（OR）=0.87，P=7.9×10⁻⁸；rs620861：OR=0.90，P=4.8×10⁻⁸）。五个连锁不平衡区域中的八个SNP与前列腺癌易感性独立相关。
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